Born in Michigan in 1980, Colby Keller was raised in Texas, attending the University of Houston for undergraduate studies. He then enrolled in the Maryland Institute College of Art, where he attained a Master of Fine Arts, Visual and Performing Arts.

Keller entered the world of gay porn in 2004, filming with Sean Cody. Since then, Keller has filmed with most major gay adult studios including Randy Blue, Titan Men, Falcon, CockyBoys and Men.com.

In addition to his long-standing porn career, Keller has also made a name for himself with his long-standing blog, The Big Shoe Diaries, his sex advice video series with Manhunt, and his various art projects, including an art/porn collaboration series entitled Colby Does America. This series featured Keller filming porn videos in every state across America, as well as some provinces in Canada.